发明名称 |
ANTI-MPL ANTIBODIES |
摘要 |
<p>Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.</p> |
申请公布号 |
EP1616881(A4) |
申请公布日期 |
2008.08.27 |
申请号 |
EP20040820316 |
申请日期 |
2004.12.10 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUNODA, HIROYUKI;NAKANO, KIYOTAKA;ORITA, TETSURO;TSUCHIYA, MASAYUKI;HIRATA, YUICHI |
分类号 |
C07K16/28;A61K39/395;C12N5/06;C12N15/11 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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