发明名称 |
Variants of hepatitus B virus with resistance to anti-viral nucleoside agents and applications thereof |
摘要 |
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other antagonists of HBV DNA polymerase activity and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants. These assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular the resistant HBV variants of the present invention. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus. |
申请公布号 |
ZA200702632(B) |
申请公布日期 |
2008.08.27 |
申请号 |
ZA20070002632 |
申请日期 |
2007.03.29 |
申请人 |
MELBOURNE HEALTH;FUNDACION INVESTIGACION Y EDUCACION EN SIDA |
发明人 |
SHELDON, JULIE;RODES, BERTA;SORIANO, VINCENT;BARTHOLOMEUSZ, ANGELINE INGRID |
分类号 |
A61K;C12N;C12Q |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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