发明名称 |
Chlamydia pneumoniae genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
摘要 |
<p>The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of <Italic>Chlamydia pneumoniae,</Italic> such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the <Italic>Chlamydia pneumoniae</Italic> genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing <Italic>Chlamydia pneumoniae</Italic> infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular <Italic>Chlamvdia pneumoniae,</Italic> infections.</p> |
申请公布号 |
EP1854885(A3) |
申请公布日期 |
2008.08.27 |
申请号 |
EP20070101045 |
申请日期 |
1998.11.20 |
申请人 |
SERONO GENETICS INSTITUTE S.A. |
发明人 |
GRIFFAIS, REMY;HOISETH, SUSAN K.;ZAGURSKY, ROBERT JOHN;METCALF, BENJAMIN J.;PEEK, JOEL A.;SANKARAN, BANUMATHI;FLETCHER, LEAH DIANE |
分类号 |
A01K67/027;C12N15/31;A61K39/00;A61K39/118;A61P37/04;C07K14/295;C07K16/12;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12P21/02;C12Q1/68;C12R1/01;G01N33/53;G01N33/566;G01N37/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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