发明名称 |
Process for preparation of bicalutamide |
摘要 |
The present invention discloses a process for the synthesis of N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulphonyl]-2-hydroxy-2-methyl propanamide (Form I). The invention discloses a reagent for oxidation of N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl propanamide to N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulphonyl]-2-hydroxy-2-methyl propanamide. More particularly, the invention discloses a method of purification of N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulphonyl]-2-hydroxy-2-methyl propanamide in a mixture of methylethyl ketone and hexane giving form (I). This form (I) is useful as an active pharmaceutical and has antiandrogenic activity. |
申请公布号 |
ZA200610685(B) |
申请公布日期 |
2008.08.27 |
申请号 |
ZA20060010685 |
申请日期 |
2006.12.19 |
申请人 |
USV LIMITED |
发明人 |
TARUR, VENKATASUBRAMANIAN RADHAKRISHNAN;KADAM, SURESH MAHADEV;JOSHI, ANIL PURUSHOTTAM;GAVHANE, SACHIN BABAN |
分类号 |
C07C;C07D |
主分类号 |
C07C |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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