发明名称 |
No-anllinic derivatives of isothiazol-3(2H)-one, 1, 1-dioxides as Liver X Receptor modulators |
摘要 |
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or &bgr; (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them. |
申请公布号 |
ZA200705519(B) |
申请公布日期 |
2008.08.27 |
申请号 |
ZA20070005519 |
申请日期 |
2007.07.05 |
申请人 |
ASTRAZENECA AB. |
发明人 |
BROO, ANDERS;JUDKINS, ROBERT;LINDSTEDT-ALSTERMARK, EVA-LOTTE;SWANSON, MARIANNE;BRICKMANN, KAY;HOLM, PATRIK;LI, LANNA;SANDBERG, PERNILLA;WEIDOLF, LARS |
分类号 |
A61K;A61P;C07D;C07D275/02;C07D275/03;C07D417/12;C07D417/14 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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