IMPROVEMENTS RELATING TO ENCAPSULATION OF BIOACTIVE AGENTS

摘要

Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)- in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5 dl/g, and methods for their preparation. DNA release is modified through use of low i.v. PLG. A particle production method for scale-up uses a blender that avoids excessive shear damage to DNA being encapsulated.