| 摘要 |
The present invention concerns the compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinа-а=а-аrepresents a divalent radical selected from N-CH=CH-CH, N-CH-N-CH or CH-CH=N-CH; Z represents NH; Y represents -Calkyl-, -Саlkyl-NR-Саlkуl-, -Саlkyl-NН-СО- or -CO-NH-Calkyl-; Xrepresents -О- or -NR-; Xrepresents -Сalkyl-, -O-Сalkyl, -О- or -О-CH; Rrepresents hydrogen or halo; Rrepresents hydrogen, cyano, halo, hydroxycarbonyl-Сalkyloxycarbonyl-, Het-carbonyl- or Ar; Rrepresents hydrogen; Rrepresents hydroxy,Сalkyloxy-, Ar-Сalkyloxy or RrepresentsСalkyloxy substituted with one or where possible two or more substituents selected fromСalkytoxy- or Het-; Rrepresents hydrogen; Rrepresents hydrogen,Сalkyl- orСalkyl-oxy-carbonyl-; Rrepresents Het-Сalkyl, in particular morpholinyl-Сalkyl; Hetrepresents a heterocycle selected from morpholinyl or piperidinyl optionally substituted withСalkyl-, preferably methyl; Hetrepresents morpholinyl; Hetrepresents a heterocycle selected from morpholinyl or pyrrolidinyl; Arrepresents phenyl; Arrepresents phenyl optionally substituted with cyano. |
