发明名称 Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases
摘要 In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent antimonials that can be used in accordance with the present invention may be any such compounds which are anti-leishmaniasis agents. The therapeutic composition of this embodiment contains an effective amount of pentavalent antimonial that can be used in treating infectious diseases. The types of diseases that can be treated with the present invention include, but are not limited to, the following: diseases associated with PTPase activity, immune deficiency, cancer, infections (such as viral infections), hepatitis B, and hepatitis C. The types of cancers that the present embodiment can be used to treat include those such as lymphoma, multiple myeloma, leukemia, melanoma, prostate cancer, breast cancer, renal cancer, bladder cancer. The therapeutic composition enhances cytokine activity. The therapeutic composition may include a cytokine, such as interferon alpha, interferon beta, interferon gamma, or granulocyte/macrophage colony stimulating factor.
申请公布号 US7416723(B2) 申请公布日期 2008.08.26
申请号 US20020238007 申请日期 2002.09.09
申请人 THE CLEVELAND CLINIC FOUNDATION 发明人 YI TAOLIN
分类号 A61K45/00;A01N55/02;A01N59/16;A61K31/29;A61K31/496;A61K31/555;A61K38/19;A61K38/21 主分类号 A61K45/00
代理机构 代理人
主权项
地址