Process for the preparation of Tazobactam in pure form

摘要

An improved process for the purification of tazobactam or its derivatives of the formula (I) wherein R represents hydrogen, C₁-C₆alkyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, o-chlorobenzyl, benzyl or diphenylmethyl, which comprises the steps of: i) slurrying the compound of formula (I) containing the impurity of the formula (V) using a solvent in the presence or absence of tartaric acid with or without the presence of water at 20-50° C. and ii) isolating the compound of formula (I) in pure form.