| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a gene and its encoded protein, termed 161P2F10B, expressed in certain cancers, and to provide diagnostic and therapeutic methods and compositions useful in the management of cancers that express 161P2F10B. <P>SOLUTION: A novel gene 0161P2F10B (also designated as 161P2F10B) and its encoded protein, and variants thereof, are described, wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization. <P>COPYRIGHT: (C)2008,JPO&INPIT |
