NOVEL SUBSTITUTED BIS-1, 2, 4-TRIOXANES AND A PROCESS FOR PREPARATION THEREOF

摘要

The present invention relates to novel substituted bis-1, 2, 4-trioxanes i.e. compounds containing two 1, 2, 4-trioxane moieties of general formula (6) useful as antimalarial agents. This invention also relates to a process for the preparation of novel substituted bis-1, 2, 4-trioxanes i.e. compounds having two 1, 2, 4-trioxanes moieties. More particularly the present invention provides a process for the preparation of bis-1, 2, 4-trioxanes of general formula (6) wherein R₁ and R₂ represents methyl, or part of a cyclic system such as cyclopentane, cyclohexane, adamantane and A is a spacer such as oxygen or oxygen substituted aromatic moieties. These bis-1, 2, 4-trioxanes of general formula (6) are new compounds and are useful as antimalarial agents. These compounds have been tested against multi-drug resistant malaria in mice and have shown promising antimalarial activity. This invention, thus relates to pharmaceutical industry.