| 摘要 |
An alternatively spliced form of transforming growth factor-beta2 (TGF-beta2), herein denoted Delta6-TGF-beta2 is disclosed. Delta6-TGF-beta2 differs from TGF-beta2 in the sequence of the three C-terminal exons. This novel protein is secreted, induced by cytotoxic stress in hematopoietic stem cells, and specifically blocks the enhancing effects of TGF-beta2 on adult stem cells. Delta6-TGF-beta2 can be used to protect stem cells from cytotoxic stress, and to enhance maintenance of these cells in vitro during retroviral transduction. In addition, Delta6-TGF-beta2 can be used to slow aging and extend longevity.
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