发明名称 |
Method For the Diagnosis and Prognosis of Demyelinating Diseases and For the Development of Medicaments Against Demyelinating Diseases |
摘要 |
The present invention refers to the use of glutamate transporters, glutamate and EGF to detect the presence of demyelinating diseases in a subject, to determine the status or severity of the same or to monitor the effects of a therapy administered to a subject who suffers from such diseases; to the use of the said markers for the searching, identification, development and evaluation of the efficacy of compounds for the treatment of such diseases, with a view to developing new drugs; to the use of compounds which promote the expression of the EAAT1 and EAAT2 transporters, as well as EGF for the treatment of demyelinating diseases. In a preferred embodiment, the methods and compounds of the invention are applicable to MS.
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申请公布号 |
US2008200384(A1) |
申请公布日期 |
2008.08.21 |
申请号 |
US20060915324 |
申请日期 |
2006.05.22 |
申请人 |
UNIVERSIDAD DEL PALS VASCO |
发明人 |
ALMAU CARLOS MATUTE;GARCIA MARIA DOMERCQ;SAMARTIN ALBERTO PEREZ;CERDA FERNANDO PEREZ;ILLARRAMENDI AINARA VALLEJO;GALNARES ESTIBALIZ ETXEBARRIA;PAMPLIEGA ORMAETXEA OLATZ;DIAZ PABLO VILLOSLADA;ZARRANZ ALFREDO RODRIGUEZ-ANTIGUEDAD |
分类号 |
A61K38/16;A61P25/00;C12Q1/68;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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