5'-SUBSTITUTED-2'-F MODIFIED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

摘要

The present invention provides 5'-substituted-2'-F nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In one preferred embodiment the nucleoside analogs have either (R) or (5)-chirality at the 5'-position. These nucleoside analogs are expected to be useful for enhancing properties of oligomeric compounds including nuclease resistance.