| 摘要 |
Provided herein is a microRNA, specifically, ß-myosin microRNA, compositions comprising ß-myosin microRNA and methods of inhibiting or reducing expression of ß-myosin microRNA. Also provided are genetically modified cells and animals comprising exogenous ß-myosin microRNA. Provided herein are methods of screening for agents that modulate ß-myosin microRNA expression. In addition, methods of identifying target genes that are regulated by ß-myosin microRNA and methods of modulating such genes are described. Methods of diagnosing or determining whether a subject is at risk for a cardiovascular disorder are also described.
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