| 发明名称 | Methods of treating anaemia | ||
| 摘要 | The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method. | ||
| 申请公布号 | US9394568(B2) | 申请公布日期 | 2016.07.19 |
| 申请号 | US201514978183 | 申请日期 | 2015.12.22 |
| 申请人 | Kymab Limited | 发明人 | Clube Jasper Rupert |
| 分类号 | A61K39/395;C12Q1/68;C07K16/28;C07K16/18;C07K16/22;C07K16/40 | 主分类号 | A61K39/395 |
| 代理机构 | Nixon Peabody LLP, David S. Resnick | 代理人 | Nixon Peabody LLP, David S. Resnick ;Karttunen Contarino Leena H.;Kling Nicole D. |
| 主权项 | 1. A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering a trap, an antibody or an antibody fragment that binds specifically to BMP6 to the human haemodialysis patient, wherein the trap, antibody or antibody fragment comprises a constant region selected from: (a) a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO: 73 or an Arg at position 289 shown in SEQ ID NO: 73; and (b) a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO: 42 or a Leu corresponding to position 206 of SEQ ID NO: 42; and wherein the human comprises (i) a TMPRSS6 nucleotide sequence comprising a SNP rs855791; rs2543519; rs2235324; or rs1421312; and (ii) a constant region gene segment encoding said selected constant region; or said patient expresses antibodies comprising said selected constant region. | ||
| 地址 | Cambridge GB | ||