发明名称 |
PEPTIDES THAT TARGET TO TUMOR BLOOD VESSELS OF LUNG CANCER AND APPLICATIONS THEREOF |
摘要 |
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCED mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCED mice. |
申请公布号 |
WO2008100482(A2) |
申请公布日期 |
2008.08.21 |
申请号 |
WO2008US01810 |
申请日期 |
2008.02.12 |
申请人 |
ACADEMIA SINICA;NATIONAL TAIWAN UNIVERSITY;WU, HAN-CHUNG;LIN, CHIN-TARNG;LEE, TONG-YOUNG;KUO, SZU-YAO |
发明人 |
WU, HAN-CHUNG;LIN, CHIN-TARNG;LEE, TONG-YOUNG;KUO, SZU-YAO |
分类号 |
A61K9/127;A61K47/48;C07K7/04 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|