NEW PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINES DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ESSENTIALLY AS IKK INHIBITORS

摘要

The invention relates to products of the formula (I) in which : R is H or HaI; R2, R3 and R4 are selected from H, HaI, CN, CONH2, CONHaIk, CON(alk)2, alkyl and alkoxy optionally substituted by HaI, CN, CONH2, CONHaIk, CON(alk)2, OH or 0CH3, with one or two of R2, R3 and R4 representing H or R2, R3 and R4 all representing methoxy; z is S02 or CO; and N(D) (W) is such as W is -cycle (Y) and D is H, cycloalkyl, alkyl, alkenyl, alkynyl, optionally substituted; cycle (Y) with Y is 0, S So, S02, NRlO, C=O, CF2, CH-0R8 or CH-NR8R9; or W and D form together with N a cycle (N) substituted by R1 and R6 so that, e.g., R1 is -X1-R7 with X1 being -(CH2)m- and R6 being H, OH, -CH20H, -CO- N-, -C02H, -C02alk; and R7 is heterocycloalkyl, aryl, heteroaryl, optionally substituted; with m = 1 - 3. The invention relates to said products under all their isomeric forms and to their salts, as drugs essentially used as IKK inhibitors.