发明名称 |
PROSTAGLANDIN AQUEOUS EYE DROP |
摘要 |
PROBLEM TO BE SOLVED: To make it possible to suppress a pH decrease with time and suppress even lowering of the residual ratio of an active ingredient in an aqueous eye drop of prostaglandins using boric acid and a specific nonionic surfactant. SOLUTION: The preservative-free and boric acid buffer-based eye drop of the prostaglandins comprises the prostaglandins such as latanoprost or isopropylunoprostone as the active ingredient (chief ingredient) and is regulated to pH5.0-7.0. POE caster oil and/or POE hardened caster oil and/or monostearic acid PEG are used as a solubilizer for the prostaglandins. The pH is stabilized by adding an aminocarboxylic acid having a chelating ability such as ethylenediaminetetraacetic acid (including a salt) orε-aminocaproic acid. COPYRIGHT: (C)2008,JPO&INPIT
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申请公布号 |
JP2008189567(A) |
申请公布日期 |
2008.08.21 |
申请号 |
JP20070023553 |
申请日期 |
2007.02.01 |
申请人 |
NIPPON TENGANYAKU KENKYUSHO:KK |
发明人 |
UETAKE YORIHISA;SUEISHI TOSHIHIKO;ISOGO NAOKO |
分类号 |
A61K31/5575;A61K9/08;A61K47/04;A61K47/18;A61K47/34;A61P27/02 |
主分类号 |
A61K31/5575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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