发明名称 |
Novel use of AIM3 acting as a tumor suppressor |
摘要 |
The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.
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申请公布号 |
US2008200382(A1) |
申请公布日期 |
2008.08.21 |
申请号 |
US20070902641 |
申请日期 |
2007.09.24 |
申请人 |
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION |
发明人 |
KIM SUNGHOON |
分类号 |
A61K38/17;A61K48/00;A61K31/7088;A61K38/00;C07K14/47;G01N33/574;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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