IMPROVED PROCESS FOR PREPARING ETHYL (S)-2-ETHOXY-4-[N-[1-(2- PIPERIDINOPHENYL)-3-METHYL-1-BUTYL]AMINOCARBONYL METHYL]BENZOATE AND USE THEREOF FOR THE PREPARATION OF REPAGLINIDE
摘要
Described herein is an improved, commercially viable and industrially advantageous process for the preparation of Repaglinide intermediate, ethyl (S)-2-ethoxy-4-[N-(1-(2- piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoate. The process provides the Repaglinide intermediate in higher yield and purity compared to the previously disclosed processes, thereby providing for production of Repaglinide and its pharmaceutically acceptable salts in high purity and in high yield.
申请公布号
WO2008099286(A2)
申请公布日期
2008.08.21
申请号
WO2008IB00825
申请日期
2008.02.15
申请人
ACTAVIS GROUP PTC EHF;BALLA, VENKATA, SASIDHAR;ALAPHARTHI, MADHUBABU;PRADHAN, NITIN, SHARADCHANDRA;VALGEIRSSON, JON
发明人
BALLA, VENKATA, SASIDHAR;ALAPHARTHI, MADHUBABU;PRADHAN, NITIN, SHARADCHANDRA;VALGEIRSSON, JON