NEW AMINOPYRROLO[1,2-?]INDOLE ET AMINOPYRIDAZINO[1,6-?]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

The invention relates to compounds of the formula (I) in which: X is CO or the formula (II)? R1, R4 are hydrogene, alkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), aminoalkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), hydroxyalkyl (C<SUB>1</SUB>- C<SUB>6</SUB>), arylalkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), R2, R3 are hydrogen, alkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), aminoalkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), hydroxyalkyl (C<SUB>1</SUB>- C<SUB>6</SUB>), or (R<SUB>1</SUB> and R<SUB>2</SUB>), (R<SUB>3</SUB> and R<SUB>4</SUB>) together with the carbon atoms bearing them define a carbon-carbon bond, R<SUB>5</SUB>, R<SUB>6</SUB> are hydrogen, alkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), R<SUB>7</SUB>, R<SUB>8</SUB>, are hydrogen, alkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), arylalkyl (C<SUB>1</SUB>-C<SUB>6</SUB>), alkenyl (C<SUB>2</SUB>-C<SUB>6</SUB>), alkynyl (C<SUB>2</SUB>-C<SUB>6</SUB>), a substituted alkyl (C<SUB>1</SUB>-C<SUB>6</SUB>) chain or a substituted alkynyl (C<SUB>1</SUB>-C<SUB>6</SUB>) chain, or either (R5 et R8) or (R6 et R7) together with the carbon and nitrogen atoms bearing them define an optionally substituted heterocycle with 5, 6 or 7 links, R9 is hydrogen, halogen, alkyl (Ci-C6), alkoxy (C1-C6), hydroxy, cyano, nitro, polyhalogenoalkyl (C1-C6), NR^R16, or a substituted alkyl (C1-C6) chain, n is an integer equal to 0, 1, 2, 3 or 4, R10 is hydrogen, alkyle (Ci-C6), alkenyl (C2-C6), arylalkyl (Ci-C6), polyhalogenoalkyl (Ci-C6) or a substituted alkyl (Ci-C6) chain, R11, R12 are -COOT or -CH2O-U, R13, R14 are hydrogen or alkyl (Ci-C6) or definine together with the nitrogen atom bearing them a heterocycle with 4 to 8 links, R15, R16 are hydrogen or alkyl (Ci-C6), alkenyl (C2-C6); the invention also relates to their enantiomers, diastereoisomers, N-oxides, and to their addition salts to a pharmaceutically acceptable acid or base. Application in drugs.