发明名称 Acid mediated deacylation of 6-0-trichlorogalactosucrose to trichlorogalactosucrose
摘要 A process is described for acid mediated deacylation of acyl derivatives of chlorinated sucrose compounds comprising generating a predominantly organic phase condition in a process stream requiring deacylation treatment but allowing an optimum quantity of water content which is capable of participating in a hydrolysis reaction; this objective being achieved for the said process stream by following steps of (a) adding to it alcoholic solvent in an amount such that water content of final reaction mixture is between about 5% to 0.5%, (b) adding acid chloride to the same (c) adjusting the pH to 4 by adding acetate buffer in a methanolic solution and, (d) stirring the reaction until deacylation is complete. This process can be integrated in a process for production of a chlorinated compound, involving use of dimethylformamide during the process, to achieve deacylation without decomposition of dimethylformamide as well as the chlorinated sucrose product.
申请公布号 GB2446736(A) 申请公布日期 2008.08.20
申请号 GB20080007217 申请日期 2008.04.21
申请人 PHARMED MEDICARE PVT LTD 发明人 RAKESH RATNAM;SUNDEEP AURORA;BATCHU CHANDRASHEKAR;ANANDANGOWDA PATIL
分类号 C07H1/00;C07H1/06;C07H5/02;C07H13/04 主分类号 C07H1/00
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