发明名称 |
PROCESS FOR PRODUCTION OF COMPOUND LABELED WITH RADIOACTIVE FLUORINE |
摘要 |
<p>A process for production of 18 F-FDG is provided, which can produce 18 F-FDG in a high and stable yield of synthesis. A process for production of a compound labeled with radioactive fluorine comprises the steps of: preparing a reaction solution by adding, under a hermetic condition, TATM and an inert organic solvent to a mixture containing [ 18 F]fluoride ions, a phase transfer catalyst and potassium ions; giving a reaction condition to the reaction solution under a hermetic condition to obtain 18 F-TAFDG; and subjecting the obtained 18 F-TAFDG to a deprotection process and optionally to a purification process to obtain 18 F-FDG.</p> |
申请公布号 |
EP1958953(A1) |
申请公布日期 |
2008.08.20 |
申请号 |
EP20060833735 |
申请日期 |
2006.11.30 |
申请人 |
NIHON MEDI-PHYSICS CO., LTD. |
发明人 |
HIRANO, KEIICHI;NAKAMURA, DAISAKU |
分类号 |
A61K51/00;C07H5/02;C07B61/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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