THERAPEUTIC VACCINES TARGETING HMGB1

摘要

A method is disclosed for inducing an immune response against autologous high mobility group box 1 (HMGB1) in the autologous host. The method relies on specific active immunotherapy utilising variants of HMGB1 and targeting conditions such as cancer, Alzheimer's disease, atherosclerosis, and inflammatory disturbances. Typical modes of the invention utilises modified HMGB1 polypeptides that comprise a substantial fragment of at least one of the A and B boxes of HMGB1. Also provided are variant HMGB1 polypeptides and nucleic acid fragments encoding these as well as vectors and transformed host cells.