| 摘要 |
A composition comprising a novel double-stranded RNA oligonucleotide is provided to decrease expression of tyrosinase, thereby being used to prevent formation and eliminating pigmentation marks and preventing skin browning. A cosmetic composition comprises at least one double-stranded RNA oligonucleotide of a sequence selected from the group consisting of SEQ ID : NOs. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, and 47 together with a population of cationic particulates less than or equal to 1 micrometer in size, and having a zeta potential ranging from 10 to 80 mV, wherein the composition prevents the formation of and/or eliminating pigmentation marks, and/or senescence marks, and/or for lightening and/or bleaching browned skin and/or rendering the color of browned skin uniformly. |
