发明名称 |
POSITIVE MODULATOR OF BONE MORPHOGENIC PROTEIN-2 |
摘要 |
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed. |
申请公布号 |
EP1725576(A4) |
申请公布日期 |
2008.08.20 |
申请号 |
EP20050723656 |
申请日期 |
2005.02.22 |
申请人 |
BIOSURFACE ENGINEERING TECHNOLOGIES, INC.;BROOKHAVEN SCIENCE ASSOCIATES |
发明人 |
ZAMORA, PAUL, O.;PENA, LOUIS, A.;LIN, XINHUA;TAKAHASHI, KAZUYUKI |
分类号 |
C07K5/00;A61K38/00;A61L27/34;C07H21/04;C07K14/00;C07K14/50 |
主分类号 |
C07K5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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