Vaccine

摘要

A polypeptide derived from the periplasmic space of Yersinia pestis or a fragment or a variant of said polypeptide for use as a medicament is described. Pharmaceutical compositions comprising such polypeptides, such as OppA from Yersinia pestis, are also described and claimed. In a preferred embodiments the pharmaceutical composition further comprises existing protective antigens from Y. pestis such as F1 and V antigens. Such compositions are protective in mice and may be used as a vaccine for the prophylactic or therapeutic treatment of plague.