发明名称 |
BINDING POLYPEPTIDES AND USES THEREOF |
摘要 |
<p>The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.</p> |
申请公布号 |
EP1957540(A2) |
申请公布日期 |
2008.08.20 |
申请号 |
EP20060849911 |
申请日期 |
2006.12.01 |
申请人 |
GENENTECH, INC. |
发明人 |
SIDHU, SACHDEV S.;BIRTALAN, SARA C.;FELLOUSE, FREDERIC A. |
分类号 |
C07K16/32;C07K16/28 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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