CARBOSTYRIL DERIVATIVES AS ANTITHROMBOTIC AGENTS

摘要

The present invention is directed to a carbostyril derivative of the formula (1): wherein A is lower alkylene, R is H, halogen or lower alkoxy, R1 and R2 are each lower alkyl unsubstituted or substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl unsubstituted or substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino unsubstituted or substituted by lower alkyl or cycloalkyl, R3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that wh en R and R3 are H, R1 and R2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof. The carbostyril derivatives of the present invention show antithrombotic activities, intima thickening inhibito ry activity, the platelet mass dissociating activity and increasing activity of blood flow in the brain and the peripheral vessel, and hence, are useful as medicines in the prophylaxis or treatment of various ischemic diseases.