发明名称 |
Antituberculosis compounds, Hirsutellones A, B, and C |
摘要 |
Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against Mycobacterium tuberculosis (H37Ra strain) with an MIC value of 0.78 mug/ml, while showing weak or no cytotoxicity to mammalian cells. Therefore, Hirsutellones and pharmaceutical compositions containing Hirsutellones may be useful for the treatment of tuberculosis. Also described herein are methods of isolating the Hirsutellones.
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申请公布号 |
US7414069(B2) |
申请公布日期 |
2008.08.19 |
申请号 |
US20050285522 |
申请日期 |
2005.11.21 |
申请人 |
NATIONAL CENTER FOR GENETIC ENGINEERING & BIOTECHNOLOGY, NATIONAL SCIENCE & TECHNOLOGY DEVELOPMENT AGENCY |
发明人 |
ISAKA MASAHIKO;HYWEL-JONES NIGEL LESLIE;SOMRITHIPOL SAYANH;KIRTIKARA KANYAWIM;PALITTAPONGARNPIM PRASIT;THEBTARANONTH YODHATHAI |
分类号 |
A61K31/407;C07D491/04;C12P17/00 |
主分类号 |
A61K31/407 |
代理机构 |
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主权项 |
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地址 |
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