SAL CRISTALINA DE NAPADISILATO DE 5-(2-[[6-(2,2-DIFLUORO-2-FENILETOXI)HEXIL]AMINO]-1-HIDROXIETIL)-8-HIDROXIQUINOLIN-2(1H)-ONA; COMPOSICION FARMACEUTICA; COMBINACION FARMACEUTICA; Y USO EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO ASMA O EPOC.

摘要

The present disclosure relates to crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and pharmaceutically acceptable solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and to methods of treatment comprising these pharmaceutical compositions.