摘要 |
Disclosed is a rapidly disintegrating solid dosage form comprising an active pharmaceutical ingredient, a disintegrant and a disintegration promoter, which formulation is obtainable by a wet granulation process. In one exemplified embodiment, the active pharmaceutical agent is a thrombin receptor antagonist, the disintegrant is sodium croscarmellose, and the disintegration promoter is calcium silicate. In some embodiments, the thrombin receptor antagonist is represented by the formula: or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating patients at risk for acute coronary syndrome by administering such a rapidly disintegrating solid dosage form.
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