发明名称 |
COMPOUNDS AND METHODS FOR AMINO-ALKYLENEDIOL SYNTHESIS |
摘要 |
A method of making an amino-alkylenediol and intermediate compounds useful in the method is disclosed. The method includes preparing a first intermediate compound comprising an aminoalkylene diol wherein a protecting group is linked to the amino functionality, and optionally, preparing a second intermediate compound comprising a salt of the first intermediate compound. The first intermediate compound has the structure of Formula (II ) wherein R is a divalent alkylene radical having from 2 to 20 carbon atoms, X and Y are independently a divalent linking moiety or a single bond, and Z is a protecting group. The second intermediate compound has the structure of Formula (III ) wherein R is a divalent alkylene radical having from 2 to 20 carbon atoms, X and Y are independently a divalent linking moiety or a single bond, TsO - is toluene sulfonate, and Z is a protecting group. |
申请公布号 |
WO2008077799(A3) |
申请公布日期 |
2008.08.14 |
申请号 |
WO2007EP63835 |
申请日期 |
2007.12.12 |
申请人 |
F. HOFFMANN-LA ROCHE AG;CAIN, ROBERT O.;MOORLAG, HENDRICK;TUCKER, CHARLES E.;WONG, JIM-WAH |
发明人 |
CAIN, ROBERT O.;MOORLAG, HENDRICK;TUCKER, CHARLES E.;WONG, JIM-WAH |
分类号 |
C07C213/02;C07C215/10;C07C215/20;C07C215/40;C07C215/42 |
主分类号 |
C07C213/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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