SYNTHETIC MACROCYCLIC COMPOUNDS FOR TREATING CANCER

摘要

Disclosed herein are macrocyclic compounds that are effective to inhibit cell migration. In one embodiment, the compounds have the structure: or any pharmaceutically acceptable salt or solvate thereof, wherein: m is O or 1; R<SUP>1</SUP>, R<SUP>2</SUP> and R<SUP>3</SUP> independently are H, aralkyl, acyl, lower alkyl or silyl; X is -C(O)N(R<SUP>4</SUP>)- or -C(S)N(R<SUP>4</SUP>)-; -C(O)-; -C(S)-; Y is -OC(O)-; -OC(O)N(R<SUP>5</SUP>)-; -N(R<SUP>5</SUP>)C(0)-; or -OC(O)O-; G comprises a saturated or unsaturated aliphatic chain having from 2 to about 10 atoms in the chain, the chain optionally including 1, 2, or 3 heteroatoms; the chain optionally being substituted with 1, 2 or 3 substituents independently selected from lower alkyl, -OR<SUP>6</SUP>, epoxy, aziridinyl, cyclopropyl, -NR<SUP>7</SUP>R<SUP>8</SUP> and halo; R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP> and R<SUP>8</SUP> independently are selected from H, lower alkyl and acyl. Also disclosed are methods for making and using compounds as well as pharmaceutical compositions including one or more of the disclosed macrocycles.