摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new, active palladium catalyst that enables a Suzuki-Miyaura coupling reaction in a small amount of use to proceed in a high yield under a mild reaction condition, and a method for producing a biaryl-based compound or a heterobiaryl-based compound using it. <P>SOLUTION: The palladium catalyst to be used in producing the biaryl-based compound by reacting an aromatic halide and an aromatic boronic acid in the presence of a palladium catalyst and a base is prepared by fixing palladium acetate dissolved in [1-butyl-3-methylimidazolium]PF<SB>6</SB>in a vacancy of amorphous alumina subjected to surface modification with a diethylaminopropyl residue. <P>COPYRIGHT: (C)2008,JPO&INPIT |