The invention provides an encapsulated unit dosage form for picoplatin th at is adapted for oral administration of the picoplatin containing a substan tially dry powder with about 20 to 55 wt% picoplatin in the physical form of a picoplatin particulate wherein an average picoplatin particle diameter is less than about 10 microns. The picoplatin particles are dispersed within t he powder of the formulation which includes a substantially water-soluble, w ater-dispersible, or water-absorbing carbohydrate and an effective amount of up to about 5 wt% of a lubricant.
申请公布号
CA2677639(A1)
申请公布日期
2008.08.14
申请号
CA20082677639
申请日期
2008.02.08
申请人
PONIARD PHARMACEUTICALS, INC.
发明人
BREITZ, HAZEL B.;LEIGH, ALISTAIR J.;PHILLIPS, ANGELICA;PROCYSHYN, CHRISTOPHER A.