HIGHLY TRANSCRIPTIONALLY ACTIVE CELL LINE FOR THE PRODUCION OF PROTEINS, NOTABLY FOR THERAPEUTIC APPLICATIONS

摘要

The invention relates to a method for obtaining a cell line, that compris es the steps of integrating into the genome of said cell a unique site for t he recognition of a recombinase in an area of high transcription activity of the genome of said cell, and integrating in the genome of said cell, and do wnstream from the unique recombinase recognition site, a nucleic acid sequen ce coding for a transcription termination signal. The invention also relates to cell lines obtained by said method.