USE OF SIRT7 FOR TREATING AGE-RELATED DISEASES

摘要

The present invention relates to a pharmaceutical composition comprising (i) a nucleic acid molecule encoding a protein having Sirt7 function wherein said nucleic acid molecule (a) has the sequence of SEQ ID NO: 1, 3, 5 or 7; (b) encodes a protein having the sequence of SEQ ID NO: 2, 4, 6 or 8; (c) hybridizes under stringent conditions to the molecule of (a) or (b); or (d) has an identity on the nucleic acid level of at least 80% with the molecule of (a), (b) or (c); (ii) a vector comprising the nucleic acid molecule of (i); (iii) a host cell comprising the vector of (ii); or (iv) a protein encoded by the nucleic acid molecule of (i). The pharmaceutical composition is used for example in the treatment of age-related diseases. Furthermore, the invention relates to screening methods for the identification of compounds useful in the treatment of age-related diseases.