| 摘要 |
<p>The present invention relates to a novel antagonis of the Toll-like receptor 4 (TLR-4). More specifically, the present invention relates to a lipopolysaccharide (LPS) isolated from the bacterium Bartonella, and especially Bartonella quintana, as a novel antagonist of the Toll-like receptor 4 (TLR-4). Further, the present invention relates t the use of said natural antagonist for the treatment of an autoimmune or inflammatory disease in a mammal and specifically for the treatment of rheumatoid arthritis (RA). Furthermore, the present invention relates to pharmaceutical compositions comprising a lipopolysaccharide (LPS) isolated from the bacterium Bartonella and especially Bartonella quintana.</p> |
| 申请人 |
STICHTING KATHOLIEKE UNIVERSITEIT;JOOSTEN, LEONARDUS, ANTONIUS, BERNARDUS;VAN DEN BERG, WILHELMUS, BERNARD;VAN DER MEER, JOHANNES, WILLEM MAARTEN;KULLBERG, BART-JULIAN;NETEA, MIHAI, GHEORGHE |
发明人 |
JOOSTEN, LEONARDUS, ANTONIUS, BERNARDUS;VAN DEN BERG, WILHELMUS, BERNARD;VAN DER MEER, JOHANNES, WILLEM MAARTEN;KULLBERG, BART-JULIAN;NETEA, MIHAI, GHEORGHE |
