INCREASED EFFECTIVENESS OF ALLYLAMINE DRUG COMPOUNDS

摘要

The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages The a llylamine active ingredient is prepared in an acidic environment, which alte rs the physiochemical properties of the active ingredient resulting in the i ngredient having a positive charge The positive charge and enhancers used in the formula allo for increased penetration of the active ingredient through skin and skin appendages The positively charged active ingredients are eith e dissolved in the vehicle directly or dissolved in a plurality of beads sus pended in the vehicle The bead structure minimizes the molecular diffusion o f the positively charged active ingredient and a catalytic species through t he bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.