METHOD OF PRODUCING SUCRALOSE

摘要

A method of producing sucralose is disclosed. The method of producing sucralose comprises the steps of preparing a compound (6, 1', 6'-tri- 0 -tritylsucrosepenta- acetate) by reacting sucrose, which is a starting material, with a tritylating agent to form a reaction product, and then reacting the reaction product with acetic anhydride (step 1); preparing a compound (2, 3, 4, 3', 4'-penta- 0 -acetylsucrose) by reacting the compound prepared in step 1 with hydrogen chloride gas having the same equivalent amount as the compound (step 2); preparing a compound (2, 3, 6, 3', 4'-penta- 0 -acetylsucrose) by isomerizing the compound prepared in step 2, under a base catalyst (step 3); preparing a compound (4, 1', 6'-trichloro- 4, 1', 6'-trideoxy-2, 3, 6, 3', 4'-penta- 0 -acetyl-galactosucrose) by chlorinating the compound prepared in step 3 (step 4); and preparing 4,1, 6'-trichloro-4, 1', 6'-trideoxygalactosucrose by deacetylating the compound prepared in step 4, and then filtering the deacetylated compound using a cation exchange resin (step 5).