METHODS FOR MAINTAINING BLOOD-BRAIN BARRIER INTEGRITY IN HYPERTENSIVE SUBJECTS USING A DELTA-PKC INHIBITOR

摘要

Methods for maintaining the integrity of the blood-brain barrier are described. Compounds that act to inhibit the action of the delta isozyme of protein kinase C (PKC) to prevent disruption of the blood-brain barrier in hypertensive subjects are described, to, in one embodiment, decrease the likelihood of hypertension-induced stroke or hypertension-induced encephalopathy.