发明名称 |
Homogeneous Preparations of Chimeric Protein |
摘要 |
Variant forms of chimeric protein molecules comprising a Factor VII moiety and an Fe region of an IgG1 moiety provide improved properties. The variants are more resistant to proteolytic degradation. Thus preparations of the variant forms are more homogeneous and have a longer half-life. The variant forms are used for treating cancer, atherosclerosis, psoriasis, diabetic retinopathy, wet macular degeneration, and rheumatoid arthritis.
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申请公布号 |
US2008193441(A1) |
申请公布日期 |
2008.08.14 |
申请号 |
US20040578670 |
申请日期 |
2004.11.10 |
申请人 |
ICONIC THERAPEUTICS, INC. |
发明人 |
TROWN PATRICK W.;SHERMAN MICHAEL I.;DORNBUSH KIRK |
分类号 |
A61K39/395;A01N43/04;A61K;A61K38/16;A61K39/00;A61K39/40;A61K39/42;A61P9/00;C07K16/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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