发明名称 |
Methods Of Inhibiting the Activity of Hsp90 and/or Aryl Hydrocarbon Receptor |
摘要 |
The present invention relates to a method of screening compounds for binding to hsp90 by exposing a compound to hsp90 or a polypeptide fragment thereof containing amino acid residues 538-728 of the full length protein and determining whether the compound binds to hsp90 of the polypeptide fragment thereof. Also disclosed is a method of screening compounds for inhibition of hsp90 activity. The present invention further relates to a method of screening compounds as a cancer therapeutic and a method of treating cancerous conditions. Also disclosed is a method of inhibiting transcription-inducing activity of an aryl hydrocarbon receptor in a cell and a method of modifying expression of a gene that is-activated by an aryl hydrocarbon receptor.
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申请公布号 |
US2008193932(A1) |
申请公布日期 |
2008.08.14 |
申请号 |
US20050718674 |
申请日期 |
2005.11.07 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
GASIEWICZ THOMAS A.;PALERMO CHRISTINE |
分类号 |
C12Q1/68;C12N5/06;G01N33/566 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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