发明名称 |
SYNTHESE VON HISTAMIN-DIHYDROCHLORID |
摘要 |
The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% <SMALLCAPS>L</SMALLCAPS>-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use. |
申请公布号 |
DE69939027(D1) |
申请公布日期 |
2008.08.14 |
申请号 |
DE1999639027 |
申请日期 |
1999.12.20 |
申请人 |
MAXIM PHARMACEUTICALS INC. |
发明人 |
YEH, WEN-LUNG;ANTCZAK, CASIMIR;MCGOLRICK, JEFFRY DAVID;ROTH, MICHAEL JOSEPH;WRONA, MARK |
分类号 |
C07D233/54;C07D233/64;A61K36/886;C07D;C07D233/61 |
主分类号 |
C07D233/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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