发明名称 |
COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS |
摘要 |
<p>The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.</p> |
申请公布号 |
WO2008097673(A1) |
申请公布日期 |
2008.08.14 |
申请号 |
WO2008US50289 |
申请日期 |
2008.01.04 |
申请人 |
IRM LLC;TULLY, DAVID, C.;CHATTERJEE, ARNAB, K.;VIDAL, AGNES;BURSULAYA, BADRY |
发明人 |
TULLY, DAVID, C.;CHATTERJEE, ARNAB, K.;VIDAL, AGNES;BURSULAYA, BADRY |
分类号 |
A61K31/423;A61K31/454;A61K31/4545;A61P11/00;C07K5/06;C07K5/08 |
主分类号 |
A61K31/423 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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