AZA-BRIDGED-RING COMPOUND

摘要

[PROBLEMS] To provide a compound which has an antagonistic activity on a muscarinic M3 receptor and is therefore useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as ch ronic obstructive pulmonary disease (COPD) and asthma. [MEANS FOR SOLVING PR OBLEMS] A study was made on a compound having an antagonistic activity on th e binding of a muscarinic M3 receptor. As a consequence, it is found that an aza-bridged-ring compound represented by the formula (1) or a salt thereof has an antagonistic activity on the binding of a muscarinic M3 receptor. The aza-bridged-ring compound has an antagonistic activity on the binding of a muscarinic M3 receptor and therefore can be used as a prophylactic and/or th erapeutic agent for an inflammatory disease such as chronic obstructive pulm onary disease (COPD) and asthma. (1) wherein R1 represents -H or a C1-6 alky l; R2 represents an aza-bridged-ring selected from the group consisting of t he rings represented by the formulae (a), (b), (c) and (d) below; and R3 rep resents a thienyl, a phenyl, a pyridyl, a pyrazinyl, a thiazolyl or a pyrazo lyl.