The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present inventio n is further directed to a pharmaceutical or diagnostic composition containi ng said conjugate as well as to a method of its production. The invention ad ditionally provides the use of said conjugates for the detection, determinat ion, separation and/or isolation of a specific binding partner and for the d iagnosis, prophylaxis and treatment of diseases in which the specific bindin g partner is directly or indirectly involved.
申请公布号
CA2677041(A1)
申请公布日期
2008.08.14
申请号
CA20082677041
申请日期
2008.02.11
申请人
CELARES GMBH;SCIL PROTEINS GMBH
发明人
FIEDLER, MARKUS;FIEDLER, ULRIKE;KRAEHMER, RALF;FIEDLER, ERIK;LEENDERS, FRANK;HEY, THOMAS