| 摘要 |
<p>A modified oligonucleotide, is new. A modified oligonucleotide of structure D-P(B)(A)=N-Acc (I), is new. A : 5' end of nucleotide or nucleotide chain or linker bound to solid phase; B : 3' end of nucleotide or nucleotide chain or a linker; D : OH or CH 3; Acc : electron acceptor or electron acceptor substituted with residue R; R : organic substituent; Acc : -CN, -SO 2-R', 6-membered N +> heterocycle (such as pyridinium, Pyrimidinium or chinolinium) with at least one alkylated N-atom in ortho- or para- position; and R' : amino-substituted alkyl(s), optionally substituted aryl or optionally substituted heterocycle. An independent claim is included for producing a modified oligonucleotide.</p> |
